Researchers develop synthetic HDL cholesterol nanoparticles
Atherosclerosis, a buildup of cellular plaque in the arteries, remains one of the leading causes of death globally. While high-density lipoprotein, or HDL, the so-called good cholesterol, is transferred to the liver for processing, low-density lipoprotein, or LDL, builds up in the arteries in the form of plaque.
Early detection of cellular components in the plaque that rupture and block arteries have long been held as potentially effective detection for heart diseases and their link to atherosclerosis.
A new study by University of Georgia researchers in the Franklin College of Arts and Sciences department of chemistry, published online May 13 in the Proceedings of the National Academy of Sciences, documents a technological breakthrough: Synthetic high density lipoprotein nanoparticles. A completely biodegradable synthetic version of the so-called good cholesterol, the nanoparticles represent a potential new detection and therapy regimen for atherosclerosis.